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With this belief, we integrate technology as a part of our holistic supply chain solutions. We also have an incubator program where we co-create future-ready tech-powered solutions with the Indian start-up ecosystem. Technology, when applied to logistics, has been shaping and optimising the supply chain process.
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Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia ...
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Rearrangements of the MLL (mixed lineage leukaemia) gene, and chimaeric MLL-fusion proteins, occur in a number of aggressive leukaemias including acute myeloid leukemia (AML). Tony Kouzarides and ...
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Reciprocal chromosomal translocations of the mixed lineage leukemia (MLL) gene with one of over 70 fusion partners are commonly found in a subset of aggressive leukemias including infant leukemia ...
Treatment of a cell line expressing the MLL-AF4 fusion protein with the HSP90-inhibitor 17-demethoxygeldanamycin (17-AAG) resulted in a significant decrease of HSP90α protein …
The killing effects of CD19/CD133 dual-targeting TanCAR T cells on MLL leukemic cells. a The CD19-positive SEM cells were sorted and cultured in myeloid-promoting condition for 10 days, and the ...
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Fig. 2: MLL-AF9-mediated transformation efficiency is associated with the intrinsic cycling rate of GMPs. a, b Cell cycle rates of individual iMLL-AF9 GMP lineages. The presence of single GMP was ...
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This FISH test allows different combinations of probes to be utilized based on the patient's age and clinical question, including the standard (diagnostic) B-cell lymphoblastic …
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Aim: As blast counting is subjective and the boundary between low and elevated blasts is arbitrary, we set out to propose a classification for MDS based solely on genetic abnormalities obviating the need for blast counting. Patients and Methods: The cohort comprised 735 de novo MDS. The diagnosis was established following WHO …
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Open access. Published: 23 January 2017. MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid …
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28 Citations. 3 Altmetric. Metrics. Abstract. Mature B-cell acute lymphoblastic leukemia (ALL) is typically associated with the FAB-L3 morphology and rearrangement of the MYC …
MLL is a target of chromosomal translocations in acute leukemias with poor prognosis. The common MLL fusion partner AF9 (MLLT3) can directly bind to AF4, DOT1L, BCOR, and …
Introduction. MLL‐fusion leukemias are aggressive forms of acute leukemias carrying chimeric fusion of the MLL (also called KMT2A) gene.The MLL gene encodes a histone H3 lysine 4 (H3K4) methyltransferase and is the frequent target of chromosomal translocations, resulting in the fusion of the 5′ portion of MLL to a number of different …
The KMT2A gene, or MLL, encodes a DNA-binding protein that methylates histone H3 (see 602810) lys4 (H3K4) and positively regulates expression of target genes, including multiple HOX genes (see 142980).MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia …
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The pathophysiologic mechanisms by which MLL translocations cause leukemia and the genes that serve as critical downstream targets during induction and maintenance of the leukemic phenotype are incompletely characterized. Gene expression profiling in human acute myeloid and lymphoblastic leukemias demonstrated a …
In MLL1-rearranged AML (MLL1-r), the MLL1 fusion protein (MLL-FP) causes dysregulated expression of HOXA9, MEIS1, PBX3, MEF2C and CDK6 [1, 2]. HOXA9 and its co-factor MEIS1 are leukemogenic in ...
The Company's pipeline includes SNDX-5613, a highly selective inhibitor of the Menin–MLL binding interaction, axatilimab, a monoclonal antibody that blocks the colony stimulating factor 1 (CSF-1) receptor, and entinostat, a class I HDAC inhibitor. For more information, please visit or follow the Company on Twitter and LinkedIn
After its translation, wild-type MLL1 is proteolytically cleaved by the enzyme taspase-1 (19, 20).The resulting 320-kDa N-terminal fragment (MLL-N) contains all domains except the transcriptional activation domain and the SET domain, both of which are retained by the 180-kDa C-terminal fragment (MLL-C).MLL-N and MLL-C normally associate with …
MLL-AF4 t(4;11)(q21;q23) The translocation t(4;11)(q21;q23) of MLL with AF4 results in an in-frame fusion chimeric MLL-AF4 protein. Of more than 90 translocation fusion partner genes, MLL-AF4 (KMT2A-AFF1) is the most common MLL fusion protein in patients, occurring in approximately 50% of infant and 75% adult MLL-r ALL cases [].Clinically, …
